Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.
نویسندگان
چکیده
Large granular lymphocytic (LGL) leukemia and myelodysplastic syndromes (MDSs) both typically present with unexplained cytopenias, yet these diseases are pathobiologically distinct and associated with substantial differences in prognosis and therapy. LGL leukemias, including both T-cell LGL leukemia and chronic lymphoproliferative disorder of natural killer (NK) cells, are clonal lymphoid disorders characterized by phenotypically abnormal cytotoxic T or NK cells and a typically indolent clinical course. In contrast, MDSs are clonal disorders of hematopoietic stem cells defined by ineffective hematopoiesis, morphologic dysplasia, and an elevated risk of acute myeloid leukemia.
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ورودعنوان ژورنال:
- Blood advances
دوره 1 21 شماره
صفحات -
تاریخ انتشار 2017